Recombinant human GRP75/HSPA9B protein
HSPA9 belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. HSPA9 was localized to chromosome 5, band q31, a region that is frequently deleted in myeloid leukemias and myelodysplasia (MDS), making it a candidate tumor suppressor gene, which is consistent with the biological function of its murine homologue. Also it inhibits nuclear translocation, transcriptional activation, and control of centrosome-duplication functions of p53. Recombinant human HSPA9 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
71 kDa (654aa)
Additionnal Information
References & Citations
Xie H., et al. (2000) Leukemia. 14 (12) :2128-34; ; Deocaris CC., et al. (2007) Ann N Y Acad Sci. 1119:165-75;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.5mM DTT, 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_004125.3
Uniprot Accession Number
P38646
Species
Human
AA Sequence
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