Recombinant human GADD45 beta protein

GADD45B is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45B is necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. And therefore, this protein is implicated in affecting synaptic plasticity. Recombinant GADD45B protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Growth arrest and DNA-damage-inducible beta, MYD118, Growth arrest and DNA-damage-inducible beta, GADD45B, Growth arrest and DNA-damage-inducible, beta GADD45 Beta, GADD45BETA, ADD45 beta, growth arrest and DNA-damage-inducible 45 beta, Growth arrest and DNA-damage-inducible protein, myeloid differentiation primary response gene, Myeloid differentiation primary response protein MyD118, Negative growth-regulatory protein MyD118.

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

17.8 kDa (160aa) confirmed by MALDI-TOF

Additionnal Information

GADD45 b, Growth arrest and DNA-damage-inducible beta, MYD118, Growth arrest and DNA-damage-inducible beta, GADD45B, Growth arrest and DNA-damage-inducible, beta GADD45 Beta, GADD45BETA, ADD45 beta, growth arrest and DNA-damage-inducible 45 beta, Growth arrest and DNA-damage-inducible protein, myeloid differentiation primary response gene, Myeloid differentiation primary response protein MyD118, Negative growth-regulatory protein MyD118., GAD0901-10 µg, GAD0901-20 µg, GAD0901-50 µg, GAD0901-100 µg, GAD0901-250 µg, GAD0901-500 µg, GAD0901-1 mg, GAD0901-10, GAD0901-20, GAD0901-50, GAD0901-100, GAD0901-250, GAD0901-500, GAD0901-1

References & Citations

Takekawa M., et al. (1998) Cell 95 (4), 521-30; ; Zerbini LF., et al. (2004) PNAS 101 (37), 13618-23;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5)

Scientific Category

Cell Cycle

NCBI Accession Number

NP_056490

Uniprot Accession Number

O75293

Species

Human

AA Sequence

MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER