Recombinant human FGF-12 protein

FGF12 (Fibroblast growth factor 12) is a member of the FGF superfamily of molecules which currently stands at 22 members. The FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and also plays an important role in intracellular signaling and ion exchange. Recombinant human FGF12 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Fibroblast growth factor 12, FHF1, FGF12B, Fibroblast growth factor 12, FGF12, Fibroblast growth factor 12 FGF 12, FGF 12B, FHF 1, FHF1, Fibroblast growth factor 12B, Fibroblast growth factor FGF 12b, Fibroblast growth factor homologous factor 1, Myocyte activating factor.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

22.6 kDa (201aa) confirmed by MALDI-TOF

Additionnal Information

FGF12, Fibroblast growth factor 12, FHF1, FGF12B, Fibroblast growth factor 12, FGF12, Fibroblast growth factor 12 FGF 12, FGF 12B, FHF 1, FHF1, Fibroblast growth factor 12B, Fibroblast growth factor FGF 12b, Fibroblast growth factor homologous factor 1, Myocyte activating factor., FGF0902-10 µg, FGF0902-20 µg, FGF0902-50 µg, FGF0902-100 µg, FGF0902-250 µg, FGF0902-500 µg, FGF0902-1 mg, FGF0902-10, FGF0902-20, FGF0902-50, FGF0902-100, FGF0902-250, FGF0902-500, FGF0902-1

References & Citations

Hubert T., et al. (2008) . J Comp Neurol. 507 (4) :1588-601; ; Nakayama F., et al. (2008) . J Radiat Res. 49 (5) :491-501;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol, 1mM DTT, 2mM EDTA

Scientific Category

Hormones & Cytokines

NCBI Accession Number

AAH22524.1

Uniprot Accession Number

P61328

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T