Recombinant human FABP4/A-FABP protein
Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is a carrier protein for fatty acids that is primarily expressed in adipocyte and macrophages. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome. Recombinant human FABP4 protein, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Fatty acid binding protein 4, IL-1 alpha, Hematopoietin-1, A-FABP, ALBP, FABP4, Fatty acid binding protein 4 adipocyte, AP2
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
14.7 kDa (132aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Furuhashi M., et al. (2007) .Nature. 447 (7147) :959-65; ; Shum BO., et al. (2006) .J Clin Invest. 116 (8) :2183-2192;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 2mM EDTA, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001433.1
Uniprot Accession Number
P15090
Species
Human
AA Sequence
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA
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