Recombinant human Calcipressin-1/DSCR1 protein
The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Background
Additional Info Comment and Pic
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
13.2 kDa (117aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hesser BA., et al. (2004) Blood. 104 (1) :149-58; ; Harris CD., et al. (2007) FEBS J. 274 (7) :1715-24.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 1mM DTT, 10% Glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_981962.1
Uniprot Accession Number
P53805
Species
Human
AA Sequence
MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
Frequently Asked Questions
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