Recombinant human Calcipressin-1/DSCR1 protein

The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Background

Additional Info Comment and Pic

Product Name Alternative

Calcipressin 1 isoform b, Regulator of calcineurin 1, RCAN1, Down syndrome critical region gene 1, DSCR1, Adapt78, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, CSP1, DSC1

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

13.2 kDa (117aa) confirmed by MALDI-TOF

Additionnal Information

DSCR1 isoform b, Down syndrome candidate region 1, Down syndrome candidate region 1, Down syndrome critical region protein 1, adapt78 protein, calcipressin 1, Calcipressin 1 isoform b, Down syndrome candidate region 1, DSR0701-10 µg, DSR0701-20 µg, DSR0701-50 µg, DSR0701-100 µg, DSR0701-250 µg, DSR0701-500 µg, DSR0701-1 mg, DSR0701-10, DSR0701-20, DSR0701-50, DSR0701-100, DSR0701-250, DSR0701-500, DSR0701-1