Recombinant human CIB1 protein

CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN Description: CIB1 (Calcium and integrin binding 1) is regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as integrin alpha IIb, PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Calcium and integrin binding 1, CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN, CIB1, Calcium and integrin binding 1 Calcium and integrin binding 1 (calmyrin), Calcium and integrin binding protein 1, CIB, DNA PKcs interacting protein, Human Snk interacting protein 2 to 28 mRNA complete cds, Kinase interacting protein, PRKDCIP, SIP2 28, SNK interacting protein 2 to 28.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

23 kDa (211aa) confirmed by MALDI-TOF

Additionnal Information

CIB1, Calcium and integrin binding 1, CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN, CIB1, Calcium and integrin binding 1 Calcium and integrin binding 1 (calmyrin), Calcium and integrin binding protein 1, CIB, DNA PKcs interacting protein, Human Snk interacting protein 2 to 28 mRNA complete cds, Kinase interacting protein, PRKDCIP, SIP2 28, SNK interacting protein 2 to 28., CIB0801-10 µg, CIB0801-20 µg, CIB0801-50 µg, CIB0801-100 µg, CIB0801-250 µg, CIB0801-500 µg, CIB0801-1 mg, CIB0801-10, CIB0801-20, CIB0801-50, CIB0801-100, CIB0801-250, CIB0801-500, CIB0801-1

References & Citations

Yuan W , et al , (2006) . Mol Cell Biochem. 26 (22) : 8507; ; Yuan , et al , (2006) . J Cell Biol. 172 (2) :169-75

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_006375

Uniprot Accession Number

Q99828

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRTVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L