Recombinant human CIB1 protein
CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN Description: CIB1 (Calcium and integrin binding 1) is regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as integrin alpha IIb, PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
23 kDa (211aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yuan W , et al , (2006) . Mol Cell Biochem. 26 (22) : 8507; ; Yuan , et al , (2006) . J Cell Biol. 172 (2) :169-75
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_006375
Uniprot Accession Number
Q99828
Species
Human
AA Sequence
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