Recombinant human BMP-4 (monomer) protein

Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF-beta superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva. Recombinant BMP-4 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Product Specifications

Product Name Alternative

ZYME, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP4, BMP2B1, BMP2B

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

13.2 kDa (117aa) confirmed by MALDI-TOF

Additionnal Information

ZYME, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP4 (monomer), BMP4, BMP2B1, BMP-2B, BMP2B, BMP 4, BMP0904-10 µg, BMP0904-20 µg, BMP0904-50 µg, BMP0904-100 µg, BMP0904-250 µg, BMP0904-500 µg, BMP0904-1 mg, BMP0904-010, BMP0904-020, BMP0904-050, BMP0904-100, BMP0904-250, BMP0904-500, BMP0904-01M