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Recombinant human GRP78/HSPA5 protein

Binding immunoglobulin protein (BiP) belongs to the family of ~70 kDa heat shock proteins (HSP 70) . It is a stress response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding as well as for the maintenance of cell homeostasis and the prevention of apoptosis. Recombinant human BIP protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Heat shock protein family A member 5, Heat shock 70kD protein 5, HSP70 family protein 5, Glucose-regulated protein 78kD, Binding-immunoglobulin protein, BiP, Endoplasmic reticulum chaperone BiP, Glucose-regulated protein 78kDa, Immunoglobulin heavy chain-binding protein

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

71 kDa (640aa)

Additionnal Information

GRP78, HSPA5, Binding immunoglobulin protein, HSPA5, heat shock 70kDa protein 5, GRP78, glucose-regulated protein 78kD, MIF2, Binding immunoglobulin protein, BIP, Binding immunoglobulin protein 78 kDa glucose regulated protein, Endoplasmic reticulum lumenal Ca2+ binding protein grp78, FLJ26106, Glucose Regulated Protein 78kDa, GRP 78, GRP78, Heat Shock 70kDa Protein 5, HSPA 5, Immunoglobulin Heavy Chain Binding Protein., BIP0901-10 µg, BIP0901-20 µg, BIP0901-50 µg, BIP0901-100 µg, BIP0901-250 µg, BIP0901-500 µg, BIP0901-1 mg, BIP0901-10, BIP0901-20, BIP0901-50, BIP0901-100, BIP0901-250, BIP0901-500, BIP0901-1

References & Citations

Lee LC., et al. (2009) Clin Chim Acta. 400 (1-2) :56-62.; ; Racek T., et al. (2008) J Biol Chem. 283 (49) :34305-14.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Heat Shock Proteins

NCBI Accession Number

NP_005338.1

Uniprot Accession Number

P11021

Species

Human

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