Recombinant human BIGH3/TGFBI protein

BIGH3, also known as TGFBI and betaig-h3, is an extracellular matrix protein induced by transforming growth factor (TGF) -beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain) . Recombinant human BIGH3 protein (fourth FAS domain) was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, BIGH3, CSD3, LCD1, CSD1, CSD2, Transforming growth factor, Beta-induced, 68kD, CDB1, CDGG1

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

14.5 kDa (135aa) confirmed by MALDI-TOF

Additionnal Information

B IG-H3, TGFBI, BIGH3, BIGH3, Fasciclin domain 4, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, Transforming growth factor-beta-induced protein ig-h3, RGD containing collagen associated protein, Beta ig h3, AI747162, big h3, CSD3, Kerato epithelin, LCD1, MGC150270, RGD CAP, TGFBI transforming growth factor, beta induced, 68kDa, AI181842, Beta ig, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, EBMD, Transforming growth factor beta induced protein ig h3., BIG0601-10 µg, BIG0601-20 µg, BIG0601-50 µg, BIG0601-100 µg, BIG0601-250 µg, BIG0601-500 µg, BIG0601-1 mg, BIG0601-10, BIG0601-20, BIG0601-50, BIG0601-100, BIG0601-250, BIG0601-500, BIG0601-1

References & Citations

Billings PC, et al. (2002) . J Biol Chem. 277. 28003-28009; ; Munier FL. et al. (2002) . Invest Ophthalmol Vis Sci. 43.949-954.; ; Jung-Eun Kim, et al. (2000) J Biol Chem. 275. 30907-30915;