Recombinant mouse OPG/TNFRSF11B protein
Tnfrsf11b, also known as tumor necrosis factor receptor superfamily member 11B, is a member of the tumor necrosis factor receptor TNFR superfamily. It inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Also It plays a role in preventing arterial calcification. Recombinant mouse Tnfrsf11B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Product Name Alternative
Tumor necrosis factor receptor superfamily member 11B isoform 1, Osteoclastogenesis inhibitory factor, Osteoprotegerin, OCIF, OPG, TR1
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Molecular Weight
44.4 kDa (388aa)
Additionnal Information
References & Citations
Min H., et al. (2000) J Exp Med. 192:463-474.; ; Simonet WS., et al. (1997) Cell. 89:309-319.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_032790
Uniprot Accession Number
O08712
Species
Mouse
N Terminal Sequence
Glu 22
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