Recombinant mouse VEGFR1/Flt-1 protein

VEGFR1 (Vascular Endothelial Growth Factor Receptor 1), also known as FLT-1 (Fms-like Tyrosine Kinase 1), belongs to the class III subfamily of receptor tyrosine kinases. While VEGFR1, VEGFR2, and VEGFR3 are mainly expressed on endothelial cells, VEGFR1 is uniquely expressed on macrophages and primarily plays inhibitory roles. Inhibitors of VEGFR are used in cancer treatment. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB, and PGF, playing essential roles in the development of embryonic vasculature, regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 binds VEGF with higher affinity than VEGFR2 but exhibits weaker kinase activity. The VEGF-kinase ligand/receptor signaling system is crucial for vascular development and the regulation of vascular permeability. Recombinant mouse VEGFR1/Flt-1, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.