Recombinant human TrkB protein
TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
HEK293
Antigen Species
Human
Tag
HIgG-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
70.3kDa (632aa)
Additionnal Information
References & Citations
Yeo GS., et al. (2004) Nat Neurosci. 7:1187-1189.; ; Banfield MJ., et al. (2001) Structure. 9:1191-1199.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_001018074.1
Uniprot Accession Number
Q16620
Species
Human
N Terminal Sequence
Cys31
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