Recombinant human TrkB protein

TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.