Recombinant human TrkB protein

TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

GP145-TrkB, trk-B, TRKB, NTRK2, OBHD, BDNF/NT-3 growth factors receptor isoform c, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B

Expression System

HEK293

Antigen Species

Human

Tag

HIgG-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

70.3kDa (632aa)

Additionnal Information

ATGP4152-10 µg, ATGP4152-20 µg, ATGP4152-50 µg, ATGP4152-100 µg, ATGP4152-250 µg, ATGP4152-500 µg, ATGP4152-1 mg, ATGP4152, ATGP4152-020, ATGP4152-050, ATGP4152-100, ATGP4152-250, ATGP4152-500, ATGP4152-01M, ATGP3264-10 µg, ATGP3264-20 µg, ATGP3264-50 µg, ATGP3264-100 µg, ATGP3264-250 µg, ATGP3264-500 µg, ATGP3264-1 mg, ATGP3264, ATGP3264-020, ATGP3264-050, ATGP3264-100, ATGP3264-250, ATGP3264-500, ATGP3264-01M