Recombinant human Frizzled-10 protein

Frizzled-10, also known as CD350, is a member of the G-protein coupled receptor Fz/Smo family. Frizzled-10 is expressed during embryogenesis in the primitive streak, dorsal neural tube, developing brain, limb bud, and airway epithelium. In the adult, it is expressed in placenta, gastric glands, and colon and renal tubule epithelial cells. It is a receptor for Wnt proteins and up-regulated in some cancers and transformed cell lines. Frizzled-10 associates with LRP5 to transduce Wnt 7a and Wnt 7b signals, resulting in the stabilization of cytoplasmic beta-catenin. Expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. It may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis or in differentiated tissues. Recombinant human Frizzled-10, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Frizzled class receptor 10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled-10, FZD10

Expression System

HEK293

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

50kDa (444aa)

Additionnal Information

ATGP4151-10 µg, ATGP4151-20 µg, ATGP4151-50 µg, ATGP4151-100 µg, ATGP4151-250 µg, ATGP4151-500 µg, ATGP4151-1 mg, ATGP4151, ATGP4151-020, ATGP4151-050, ATGP4151-100, ATGP4151-250, ATGP4151-500, ATGP4151-01M