Recombinant human TGF-beta RII protein

TGFBR2, as known as TGF-beta receptor type-2 isoform B, is a member of the serine and threonine protein kinase family and the TGF beta receptor subfamily. The type-2 receptor binds TGF-beta1 and TGF-beta3 with high affinity, and TGF-beta2 with a much lower affinity. It forms a heterodimeric complex with type1 receptor and is essential for signal transduction. Also, this protein may play an important role in TGF-beta2 binding and signaling in cells lacking TGFBR3. Recombinant human TGFBR2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human TGF-beta3 is coated at 2 µg/mL (100 ul/well) can bind Human TGF-beta RII. The ED50 range ≤ 1 µg/mL.

Product Name Alternative

TGF-beta receptor type-2 isoform B, TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF beta-RII, TGFR-2, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA with Human TGF-beta3. The ED50 range ≤ 1 µg/mL.

Molecular Weight

43.3 kDa (383aa)

Additionnal Information

TGF-b RII, TGF-beta receptor type-2 isoform B, TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF beta-RII, TGFR-2, ATGP4146-10 µg, ATGP4146-20 µg, ATGP4146-50 µg, ATGP4146-100 µg, ATGP4146-250 µg, ATGP4146-500 µg, ATGP4146-1 mg, ATGP4146-10, ATGP4146-20, ATGP4146-50, ATGP4146-100, ATGP4146-250, ATGP4146-500, ATGP4146-1, ATGP3355-10 µg, ATGP3355-20 µg, ATGP3355-50 µg, ATGP3355-100 µg, ATGP3355-250 µg, ATGP3355-500 µg, ATGP3355-1 mg, ATGP3355-10, ATGP3355-20, ATGP3355-50, ATGP3355-100, ATGP3355-250, ATGP3355-500, ATGP3355-1