Recombinant human TGF-beta RII protein
TGFBR2, as known as TGF-beta receptor type-2 isoform B, is a member of the serine and threonine protein kinase family and the TGF beta receptor subfamily. The type-2 receptor binds TGF-beta1 and TGF-beta3 with high affinity, and TGF-beta2 with a much lower affinity. It forms a heterodimeric complex with type1 receptor and is essential for signal transduction. Also, this protein may play an important role in TGF-beta2 binding and signaling in cells lacking TGFBR3. Recombinant human TGFBR2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human TGF-beta3 is coated at 2 µg/mL (100 ul/well) can bind Human TGF-beta RII. The ED50 range ≤ 1 µg/mL.
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human TGF-beta3. The ED50 range ≤ 1 µg/mL.
Molecular Weight
43.3 kDa (383aa)
Additionnal Information
References & Citations
Wrana JL., et al. (1992) Cell 71:1003-1014.; ; Halper B., et al. (2015) Exerc. Immunol. Rev. 21:154-163.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Protease inhibitors
NCBI Accession Number
NP_003233.4
Uniprot Accession Number
P37173
Species
Human
N Terminal Sequence
Thr23
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