Recombinant human PIGF-2 protein
PIGF-2, as know as placenta growth factor, is a member of the VEGF sub-family that a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. It is ultimately associated with angiogenesis. Specifically, it plays a role in trophoblast growth and differentiation. Also it is a potential biomarker for preeclampsia, a condition in which blood vessels in the placenta are too narrow, resulting in high blood pressure. Under normal physiologic conditions, it is also expressed at a low level in other organs including the heart, lung, thyroid, and skeletal muscle. Recombinant human PIGF-2, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human PIGF-2 is coated at 2 µg/mL (100 ul/well) can bind Human VEGFR1/Flt-1 (CAT# ATGP4101) in a Functional ELISA assay.
Product Name Alternative
Placental growth factor, placenta growth factor isoform 1, PGF, D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human VEGFR1/Flt-1 (CAT# ATGP4101) .
Molecular Weight
18.1kDa (158aa)
Additionnal Information
References & Citations
Asma Khalil., et al, (2008) PLoS One. 3:e2766.; ; Khurana R., et al, (2005) Circulation. 111:2828-2836.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Angiogenesis, Cardiovascular
NCBI Accession Number
NP_002623.2
Uniprot Accession Number
P49763-3
Species
Human
N Terminal Sequence
Leu19
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