Recombinant human TMIGD2/CD28H protein

TMIGD2, also known as IGPR-1, is a member of the Immunoglobulin family. This protein shares approximately 10% amino acid sequence identity with CD28, CTLA­4, ICOS, and PD­1. The immunoglobulin domain of TMIGD2 was predicted to be Ig V fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein. It plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, co-stimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. It is constitutively expressed on naive T and NK cells. Similar to the interaction of B7 with CD28, the interaction of TMIGD2 with B7­H7 activates the Akt­dependent signaling cascade and promotes the proliferation and activation of newly generated peripheral effector and memory T cells. Also, it interacts with multiple cytoskeletal proteins. Recombinant human TMIGD2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.