Recombinant human Crystallin alpha B/CRYAB protein

Alpha crystallins are composed of two gene products ; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) . They act as molecular chaperones and hold them in in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of alpha-crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases.

Product Specifications

Product Name Alternative

CRYAB, CRYA2, CRYAB (Crystallin alpha B), Rosenthal fiber component, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Alpha crystallin B chain, AACRYA, Alpha (B) crystallin, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

21.2 kDa (183aa)

Additionnal Information

AACRYA, Alpha crystallin B chain, Alpha (B) crystallin, Alpha-crystallin B chain, Crya2, Crya-2, Cryab, CRYAB (Crystallin alpha B), Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HspB5, NY REN 27 antigen, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, ATGP4137-10 µg, ATGP4137-20 µg, ATGP4137-50 µg, ATGP4137-100 µg, ATGP4137-250 µg, ATGP4137-500 µg, ATGP4137-1 mg, ATGP4137-10, ATGP4137-20, ATGP4137-50, ATGP4137-100, ATGP4137-250, ATGP4137-500, ATGP4137-1

References & Citations

Hasan, A., et al. (2002) Biochemistry 41 (52) 15876-15882; ; Kamradt, M.C.., et al (2002) J. Biol.Chem. 277 (41) 38731-38736 ; ; Reddy, G.B., et al (2002) FEBS lett. 522 (1-3) 59-64 ; ; Ito, H., et al (2002) J.Biochem.131 (4) 593-603;