Recombinant human TGF-beta RI/ALK-5 protein
TGFBR1, also known as TGF-beta receptor type-1 isoform 1, is a single-pass type 1 membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. This protein is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Also, it plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Diets syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5) . Recombinant human TGFBR1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Mouse CD105 (CAT# ATGP3361) is coated at 10 µg/mL (100 ul/well) can bind Human TGF-beta RI/ALK-5. The ED50 range ≤ 2 µg/mL.
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Mouse CD105 (CAT# ATGP3361) . The ED50 range ≤ 2 µg/mL.
Molecular Weight
38kDa (342aa)
Additionnal Information
References & Citations
Wrana JL., et al, (1992) Cell 71:1003-1014.; ; Huse M., et al, (1999) Cell 96:425-436.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Angiogenesis, Cardiovascular
NCBI Accession Number
NP_004603.1
Uniprot Accession Number
P36897
Species
Human
N Terminal Sequence
Ala
AA Sequence
LLPGATA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VEL
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