Recombinant human IFN-omega protein
IFN-omega, also known as interferon-omega, is a member of a family of proteins with antiviral, growth inhibitory and immunomodulatory activity. Type I IFNs consist of IFN alpha, beta, tau, and omega and bind to the type I IFN receptor, whereas IFN-gamma is the only type II IFN and is specific for the type II IFN receptor. IFN-omega is produced primarily in leukocytes in response to viral infection, and it has biological activities. Also, it was reported that IFN-omega could inhibit the growth of human tumors in vivo. Recombinant human IFN-omega, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human Interferon-omega stimulates cytotoxicity of the TF-1 human erythroleukemic cells. The ED50 range ≤0.07 ng/mL.
Product Name Alternative
Interferon omega-1, interferon alpha-II-1, interferon omega 1, IFNW1, IFN-omega 1
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured in a cytotoxicity assay using TF-1 human erythroleukemic cells. The ED50 range ≤0.07 ng/mL.
Molecular Weight
20.9kDa (180aa)
Additionnal Information
References & Citations
Seo Y., et al, (2011) Pharmacology. 87:224-231.; ; Adolf G.R., et al, (1991) . Biochim. Biophys. Acta.1089:167-174.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology, Hormones & Cytokines
NCBI Accession Number
NP_002168.1
Uniprot Accession Number
P05000
Species
Human
N Terminal Sequence
Leu 22
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