Recombinant human FLRT3 protein

FLRT3, also known as leucine-rich repeat transmembrane protein, is a member of the fibronectin leucine rich transmembrane protein (FLRT) family. It contains 10 N-terminal leucine-rich repeats flanked by cysteine-rich areas, and a juxtamembrane fibronectin type III domain. And It expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. The members of the FLRT family may have a function in cell adhesion and/or receptor signaling. The fibronectin domain is responsible for binding to FGF receptors, and is thought to regulate FGF signaling during development. The LRR domains are responsible for both the localization in areas of cell contact and homotypic cell-cell association. Also, It may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge. Recombinant human FLRT3, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.