Recombinant human APP/Protease Nexin II protein

APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. It has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebral arterial amyloidosis. Recombinant human APP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.