Recombinant mouse Lactate Dehydrogenase A/LDHA protein
Ldha, also known as L-lactate dehydrogenase A chain isoform 1, is a member of the LDH/MDH superfamily and LDH family. It catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. This protein is found predominantly in muscle tissue. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It plays an important role in the development, invasion and metastasis of malignancies. Recombinant mouse Ldha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Product Name Alternative
L-lactate dehydrogenase A chain isoform 1, LDH muscle subunit (LDH-M), Ldha, 17R2, Ldh1, Ldhm, LDH-A, LDH muscle smb
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Enzyme Activity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Molecular Weight
37.5 kDa (340aa)
Additionnal Information
References & Citations
Rong Y., et al. (2013) Tumour Biol. 34 (3) :1523-1530.; ; Merkle S., et al. (1992) Genetics. 131 (2) :413-421.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Metabolism
NCBI Accession Number
NP_034829
Uniprot Accession Number
P06151
Species
Mouse
N Terminal Sequence
Met1
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