Recombinant human GP1BB protein

GP1BB, also known as glycoprotein Ib platelet subunit beta/CD42c, is a member of platelet receptor family. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. This complex is composed of GPIb alpha attached to GPIb beta and non-covalently complexed with GPIX and GPV. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in GP1BB have been associated with Bernard–Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. Recombinant human GP1BB, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Glycoprotein Ib platelet subunit beta, BDPLT1, BS, CD42C, GPIBB, GPIbbeta, Antigen CD42b-beta, GP-Ib beta, GPIb-beta, GPIbB, Platelet glycoprotein Ib beta chain

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

14kDa (131aa)

Additionnal Information

ATGP4114-10 µg, ATGP4114-20 µg, ATGP4114-50 µg, ATGP4114-100 µg, ATGP4114-250 µg, ATGP4114-500 µg, ATGP4114-1 mg, ATGP4114-010, ATGP4114-020, ATGP4114-050, ATGP4114-100, ATGP4114-250, ATGP4114-500, ATGP4114-01M