Recombinant human ICAM-1/CD54 protein

ICAM-1/CD54, also known as intercellular adhesion molecule 1, is a member of the immunoglobulin superfamily. It expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFNG, TNFa, IL-1b and LPS. They are important in inflammation, immune responses and in intracellular signalling events. It is known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. It has been implicated in subarachnoid hemorrhage and expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds. Recombinant human ICAM-1/CD54, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.