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Recombinant canine IL31 protein

IL31, also known as interleukin-31, is a cytokine with an anti-parallel four-helix bundle structure in the gp130/IL-6 cytokine family. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. This protein is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2) . This protein is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Recombinant Canine IL31 was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

IL31, IL-31, Interleukin-31, Interleukin 31, CANLF

Expression System

HEK293

Antigen Species

Canine

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

15.3 kDa (136aa)

Additionnal Information

ATGP4105-10 µg, ATGP4105-20 µg, ATGP4105-50 µg, ATGP4105-100 µg, ATGP4105-250 µg, ATGP4105-500 µg, ATGP4105-1 mg, ATGP4105-10, ATGP4105-20, ATGP4105-50, ATGP4105-100, ATGP4105-250, ATGP4105-500, ATGP4105-1

References & Citations

Dillon SR., et al, (2004) Nat. Immunol. 5:752-760.; ; Diveu C., et al, (2004) Eur. Cytokine Netw. 15:291-302.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology, Hormones & Cytokines

NCBI Accession Number

NP_001159386.1

Uniprot Accession Number

C7G0W1

Species

Canine

N Terminal Sequence

Ser24

AA Sequence

SHMAPTHQLP PSDVRKIILE LQPLSRGLLE DYQKKETGVP ESNRTLLLCL TSDSQPPRLN SSAILPYFRA IRPLSDKNII DKIIEQLDKL KFQHEPETEI SVPADTFECK SFILTILQQF SACLESVFKS LNSGPQ

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