Recombinant human B7-H6 protein
B7-H6, also known as NCR3LG1, is a member of the B7 family of immune co‑stimulatory proteins. B7-H6 is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. It is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, and is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30‑dependent cell lysis. Recombinant human B7-H6, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human NCR3 is coated at 2 µg/mL (100 ul/well) can bind Human B7-H6. The ED50 range ≤500 ng/mL.
Product Name Alternative
Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, NCR3LG1, B7H6, DKFZp686O24166
Expression System
HEK293
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human NCR3. The ED50 range ≤500 ng/mL.
Molecular Weight
53.6kDa (477aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001189368.1
Uniprot Accession Number
Q68D85
Species
Human
N Terminal Sequence
Asp 25
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