Recombinant human Podocalyxin protein
Podocalyxin, also known as PODXL, is a member of the CD34 sialomucin protein family. It is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. It has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2. And Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium. It is upregulated in a number of cancers and is frequently associated with poor prognosis. Based on patient survival data, high level of PODXL transcripts in tumor cells is associated with poor prognosis in renal cancer. Recombinant human Podocalyxin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
43.1kDa (416aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.
Scientific Category
Signal Transduction, Cytoskeleton
NCBI Accession Number
NP_005388.2
Uniprot Accession Number
O00592
Species
Human
N Terminal Sequence
Asp
AA Sequence
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