Recombinant human Angiopoietin-like 7/ANGPTL7 protein
Angiopoietin-like 7, also known as Angiopoietin-related protein 7, is a member of angiopoietin-like (ANGPTL) family. Angiopoietin-like 7 have been shown to be involved in blood vessel formation or neovascularization in several models. When overexpressed in tumor cells it promotes collagen and proteoglycan deposition but inhibits tumor xenograft progression and tumor angiogenesis. It is also expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Overexpression of ANGPTL7 increases collagen expression. Thus, it could have a pathogenic role in glaucoma, and may serve as a potential therapeutic target. Recombinant human Angiopoietin-like 7, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Angiopoietin like 7, AngX, CDT6, Angiopoietin-related protein 7, ANGPTL7
Expression System
HEK293
Antigen Species
Human
Tag
HIgG-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Molecular Weight
63.2kDa (553aa)
Additionnal Information
References & Citations
Kuchtey, J., et al, (2008) Invest. Opthalmol. Visual Sci. 49:3438-3448. ; ; Oike, Y., et al, (2009) Invest. Circ. J. 73:2192. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_066969.1
Uniprot Accession Number
O43827
Species
Human
N Terminal Sequence
Gln 27
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