Recombinant human IL-18R beta/IL18RAP protein

IL-18 R beta/IL-1 R7, also known as interleukin-18 receptor accessory protein, is a member of the IL-1 family of cytokines that has multiple immunoregulatory functions. It does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Recombinant human IL-18 R beta/IL-1 R7 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

ACPL, CD218 antigen-like family member B, CD218b, CDw218b, IL-18 receptor accessory protein, IL-18RAcP, IL18RAP, IL18RB, IL18Rbeta, IL-1R accessory protein-like, IL-1R7, IL-1RAcPL, Interleukin-1 receptor 7, Interleukin-18 receptor accessory protein, Interleukin-18 receptor accessory protein isoform 1, Interleukin-18 receptor beta

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

65.4 kDa (576aa)

Additionnal Information

ACPL, CD218 antigen-like family member B, CD218b, CDw218b, IL-18 receptor accessory protein, IL-18RAcP, IL18RAP, IL18RB, IL18Rbeta, IL-18R-beta, IL-1R accessory protein-like, IL-1R7, IL-1R-7, IL-1RAcPL, Interleukin-1 receptor 7, Interleukin-18 receptor accessory protein, Interleukin-18 receptor accessory protein isoform 1, Interleukin-18 receptor beta, ATGP4073-10 µg, ATGP4073-20 µg, ATGP4073-50 µg, ATGP4073-100 µg, ATGP4073-250 µg, ATGP4073-500 µg, ATGP4073-1 mg, ATGP4073-010, ATGP4073-020, ATGP4073-050, ATGP4073-100, ATGP4073-250, ATGP4073-500, ATGP4073-01M