Recombinant human IL-18R beta/IL18RAP protein
IL-18 R beta/IL-1 R7, also known as interleukin-18 receptor accessory protein, is a member of the IL-1 family of cytokines that has multiple immunoregulatory functions. It does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Recombinant human IL-18 R beta/IL-1 R7 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
65.4 kDa (576aa)
Additionnal Information
References & Citations
Cheung H., et al, (2005) J Immunol. 174:5351-5357.; ; Chandrasekar B., et al, (2003) Biochem Biophys Res Commun. 303:1152-1158.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_003844.1
Uniprot Accession Number
O95256
Species
Human
N Terminal Sequence
Phe 20
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