Recombinant mouse DKK1 protein

Dkk-1, also known as Dickkopf-related protein 1, is a member of the Dkk protein family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Because of its antagonistic effects on the Wnt signaling pathway, it is believed that Dkk-1 is a common marker for neuronal death in neurodegenerative diseases like Alzheimer’s. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Recombinant mouse Dkk-1, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

MDkk-1, Dkk-1, Dickkopf-related protein 1, Dickkopf-1, Dickkopf WNT signaling pathway inhibitor 1

Expression System

HEK293

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS - PAGE

Molecular Weight

26.9kDa (247aa)

Additionnal Information

MDkk-1, Dkk-1, Dkk1, Dickkopf-related protein 1, Dickkopf-1, Dickkopf WNT signaling pathway inhibitor 1, ATGP4071-10 µg, ATGP4071-20 µg, ATGP4071-50 µg, ATGP4071-100 µg, ATGP4071-250 µg, ATGP4071-500 µg, ATGP4071-1 mg, ATGP4071-010, ATGP4071-020, ATGP4071-050, ATGP4071-100, ATGP4071-250, ATGP4071-500, ATGP4071-01M