Recombinant mouse DKK1 protein
Dkk-1, also known as Dickkopf-related protein 1, is a member of the Dkk protein family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Because of its antagonistic effects on the Wnt signaling pathway, it is believed that Dkk-1 is a common marker for neuronal death in neurodegenerative diseases like Alzheimer’s. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Recombinant mouse Dkk-1, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
MDkk-1, Dkk-1, Dickkopf-related protein 1, Dickkopf-1, Dickkopf WNT signaling pathway inhibitor 1
Expression System
HEK293
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
Molecular Weight
26.9kDa (247aa)
Additionnal Information
References & Citations
Krupnik, V.E. et al. (1999) Gene 238:301-13.; ; Nusse, R. et al. (2001) Nature 411:255-6.; ; Mao, J. et al. (2001) Mol. Cell 7:801-9.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 50 mM MES buffer (pH 6.5) containing 30% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_034181.2
Uniprot Accession Number
O54908
Species
Mouse
N Terminal Sequence
Thr 32
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