Recombinant human RNASE2 protein

RNASE2, is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is found in eosinophil granulocytes and closely related to the eosinophil cationic protein (RNASE3) from which it diverged 50 million years ago after the split between the old world and the new world monkeys. It is relatively neutral and has cytotoxic properties. It may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. It has also been studied in the context of defense against pathogen infection in mammals. Recombinant human RNASE2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Ribonuclease A family member 2, EDN, RAF3, RNS2, non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS - PAGE

Molecular Weight

16.5kDa (143aa)

Additionnal Information

ATGP4065-10 µg, ATGP4065-20 µg, ATGP4065-50 µg, ATGP4065-100 µg, ATGP4065-250 µg, ATGP4065-500 µg, ATGP4065-1 mg, ATGP4065-10, ATGP4065-20, ATGP4065-50, ATGP4065-100, ATGP4065-250, ATGP4065-500, ATGP4065-1

References & Citations

Rosenberg HF., et al, (2015) Int J Mol Sci. 14:15442-15455. ; ; Levin AM., et al, (2019) J Allergy Clin Immunol. 143:1791-1802.; ; Ostendorf T., et al, (2020) Immunity. 52:591-605.