Recombinant human TIE1 protein

Tie-1, as known as tyrosine kinase with immunoglobulin like and EGF like domains 1, is an angiopoitein receptor. It is expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. However it has also been shown to be expressed in immature hematopoietic cells and platelets. It upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Also, It has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. Recombinant human Tie-1, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tyrosine-protein kinase receptor Tie-1 isoform 1, tyrosine kinase with immunoglobulin like and EGF like domains 1, JTK14, TIE, TIE1, LMPHM11

Expression System

HEK293

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

106.8kDa (977aa)

Additionnal Information

ATGP4062-10 µg, ATGP4062-20 µg, ATGP4062-50 µg, ATGP4062-100 µg, ATGP4062-250 µg, ATGP4062-500 µg, ATGP4062-1 mg, ATGP4062-10, ATGP4062-20, ATGP4062-50, ATGP4062-100, ATGP4062-250, ATGP4062-500, ATGP4062-1

References & Citations

Marron MB., et al, (2000) Adv Exp Med Biol. 476:35-46.; ; Li K., et al, (2010) Blood. 115:133-139.; ; Zhang X., et al, (2020) Cancers. 12:1705.; ; Carlantoni C., et al, (2021) Dev Biol. 469:54-67.;