Recombinant human TIE1 protein
Tie-1, as known as tyrosine kinase with immunoglobulin like and EGF like domains 1, is an angiopoitein receptor. It is expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. However it has also been shown to be expressed in immature hematopoietic cells and platelets. It upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Also, It has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. Recombinant human Tie-1, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tyrosine-protein kinase receptor Tie-1 isoform 1, tyrosine kinase with immunoglobulin like and EGF like domains 1, JTK14, TIE, TIE1, LMPHM11
Expression System
HEK293
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
106.8kDa (977aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In 20 mM Tris-HCl (pH 8.0) containing 0.1M NaCl, 50% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_005415.1
Uniprot Accession Number
P35590
Species
Human
N Terminal Sequence
Ala 22
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