Recombinant mouse ALCAM/CD166 protein
ALCAM (Activated leukocyte cell adhesion molecule), also known as CD166 antigen, is a member of the Ig CAM family within the immunoglobulin superfamily. It interacts with CD6 that promotes T-cell activation and proliferation and plays a role in the binding of T- and B-cells to activated leukocytes. While expressed in a wide variety of tissues, ALCAM is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. Recently, CD166 is regarded as a potential novel breast cancer indicator and therapeutic target. Recombinant mouse ALCAM, fused to hIgG-His-tag at C-terminus, was expressed in Insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Mouse ALCAM stimulates inhibit cell adhesion of the Jurkat human acute T cell leukemia cells by CD6. This effect is more to 50%.
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Bioactivity
Molecular Weight
83.1kDa (739aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 50% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_033785
Uniprot Accession Number
Q61490
Species
Mouse
N Terminal Sequence
Trp28
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