Recombinant human Folate hydrolase 1/FOLH1 protein
PSMA1/FOLH1, as known as glutamate carboxypeptidase 2 (GCPII), is a single pass type 2 membrane protein which belongs to the peptidase M28 family. It is a zinc metalloenzyme that resides in membranes and catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) . This protein is most highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, live, stomach, small intestine colon, and the capillary endothelium of a variety of tumors. Thus, it shows a promising role in directed imaging and therapy of recurrent of metastatic disease. Recombinant human PSMA1/FOLH1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Molecular Weight
80.7kDa (717aa)
Additionnal Information
References & Citations
Rahn KA., et al, (2012) Proc. Natl. Acad. Sci. U.S.A. 109:20101-20106.; ; Schaevitz LR., et al, (2012) Dev Neurobiol 72:891-905.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Signal Transduction, Metabolism
NCBI Accession Number
NP_004467
Uniprot Accession Number
Q04609
Species
Human
N Terminal Sequence
Ala
AA Sequence
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