Recombinant human LILRB2/CD85d/ILT4 protein

LILRB2, also known as CD85d, LIR-2, and MIR10, is a member of the leukocyte immunoglobulin-like receptor (LIR) family. It is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. Among them it competes with CD8 alpha for MHC I binding but does not compete with KIR2DL1. And it binds to classical MHC I proteins as well as the non-classical HLA-G1 and HLA-F molecules. This protein is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Recombinant human LILRB2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Leukocyte Immunoglobulin-like Receptor, CD85D, CD85d, CD85 antigen-like family member D, CD85d antigen, ILT-4, ILT4, ILT4CD85d, Ig-like transcript 4, Immunoglobulin-like transcript 4, LILRB2, LIR2, LIR-2, LIR2CD85D, Leukocyte immunoglobulin-like receptor 2, MIR10, MIR-10, MIR10LILRA6, Monocyte/macrophage immunoglobulin-like receptor 10, leukocyte immunoglobulin-like receptor subfamily B member 2, leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform 1

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

48.3 kDa (444aa)

Additionnal Information

ATGP4042-10 µg, ATGP4042-20 µg, ATGP4042-50 µg, ATGP4042-100 µg, ATGP4042-250 µg, ATGP4042-500 µg, ATGP4042-1 mg, ATGP4042-10, ATGP4042-20, ATGP4042-50, ATGP4042-100, ATGP4042-250, ATGP4042-500, ATGP4042-1

References & Citations

Fanger, N.A. et al. (1998) Eur. J. Immunol. 28:3423.; ; Baudhuin, J. et al. (2013) Proc. Natl. Acad. Sci. USA 110:17957-17962.; ; Shiroishi, M. et al. (2003) Proc. Natl. Acad. Sci. USA 100:8856-8861.; ; Borges, L. et al. (1997) J. Immunol. 159:5192-5196.;