Recombinant mouse TIMP-1 protein

TIMP-1, also known as metalloproteinase inhibitor 1, is a member of the TIMP family. Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. It has been identified as a multifunctional molecule with divergent functions. Recombinant Mouse TIMP-1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Timp1, Cl, Clgi, EPA, Timp, TIMP-1, TPA-S1, Metalloproteinase inhibitor 1, Collagenase inhibitor 16C8 fibroblast, Erythroid-potentiating activity, TPA-induced protein

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

21kDa (187aa)

Additionnal Information

ATGP4040-10 µg, ATGP4040-20 µg, ATGP4040-50 µg, ATGP4040-100 µg, ATGP4040-250 µg, ATGP4040-500 µg, ATGP4040-1 mg, ATGP4040-10, ATGP4040-20, ATGP4040-50, ATGP4040-100, ATGP4040-250, ATGP4040-500, ATGP4040-1

References & Citations

M Toricelli, et al. (2013) Molecular Cancer 12:1095.; ; Gardner., et al. (2003) J. Neurosci. Res. 74:801-806.; ; Osthues A., et al. (1992) FEBS. Lett. 296:16-20.