Recombinant human IL-17RB protein

IL-17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C. It has been shown to mediate the activation of NFkappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL-17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human IL25 (CAT# ATGP4018) is coated at 2 µg/mL (100 ul/well) can bind Human IL17RB. The ED50 range ≤ 2 µg/mL.

Product Name Alternative

Interleukin-17 receptor B, CRL4, EVI27, IL17BR, IL17RH1, IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, Interleukin-17B receptor

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.25 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA with Human IL25 (CAT# ATGP4018) . The ED50 range ≤ 2 µg/mL.

Molecular Weight

57.3 kDa (514aa) Reducing conditions

Additionnal Information

ATGP4039-10 µg, ATGP4039-20 µg, ATGP4039-50 µg, ATGP4039-100 µg, ATGP4039-250 µg, ATGP4039-500 µg, ATGP4039-1 mg, ATGP4039-10, ATGP4039-20, ATGP4039-50, ATGP4039-100, ATGP4039-250, ATGP4039-500, ATGP4039-1, ATGP3061, ATGP3061-10 µg, ATGP3061-20 µg, ATGP3061-50 µg, ATGP3061-100 µg, ATGP3061-250 µg, ATGP3061-500 µg, ATGP3061-1 mg, ATGP3061-10, ATGP3061-20, ATGP3061-50, ATGP3061-100, ATGP3061-250, ATGP3061-500, ATGP3061-1