Recombinant human EphB1 protein

EphB1 also known as Ephrin type-B receptor 1, is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors. EphB1 has been shown to bind ephrin-B2, ephrin-B1, ephrin‑A3, ephrin-A1, ephrin-A4, and ephrin-B3. It binds to tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. The ephrin/Eph families also appear to play a role in angiogenesis. Recombinant human EPHB1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human EPHB1 is coated at 2 µg/mL (100 ul/well) can bind Human EFNB1 (CAT# ATGP3800) in a Functional ELISA assay.

Product Name Alternative

EPHB-1, Ephrin type-B receptor 1, Eph Receptor B1, ELK, EPH tyrosine kinase 2, EPH-like kinase 6, EK6, hEK6, HEK6, Neuronally-expressed EPH-related tyrosine kinase, NET, NETHek6, Tyrosine-protein kinase receptor EPH-2, EPHT2, soluble EPHB1 variant 1

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA with Human EFNB1 (CAT# ATGP3800) .

Molecular Weight

59.2 kDa (529aa)

Additionnal Information

ATGP4038-10 µg, ATGP4038-20 µg, ATGP4038-50 µg, ATGP4038-100 µg, ATGP4038-250 µg, ATGP4038-500 µg, ATGP4038-1 mg, ATGP4038-10, ATGP4038-20, ATGP4038-50, ATGP4038-100, ATGP4038-250, ATGP4038-500, ATGP4038-1

References & Citations

Eph Nomenclature Committee. Cell 90:403-404.; ; Pasquale, E.B. (1997) Curr. Opin. Cell Biol. 9:608-615.; ; Adams RH, et al. (1999) . Genes Dev. 13: 295-306.;