Recombinant Influenza A H7N9 Hemagglutinin/HA1 protein

H7N9/HA (hemaggulutinin1) belongs to the influenza viruses hemagglutinin family. Influenza A virus subtype H7N9 (A/H7N9) is a bird flu strain of the species Influenza virus A Influenza and Influenza hemagglutinin (HA) or haemagglutinin is a type of hemagglutinin found on the surface of the influenza viruses. An H7N9 virus was first reported to have infected humans in March 2013, in China. The CDC estimates that the H7N9 virus has the greatest potential compared with other influenza A viruses to cause a pandemic, although the risk is low, because like other type A viruses, it is not easily transmitted between people in its current form. H7N9/HA is an antigenic glycoprotein and is responsible for binding the virus to the cell that is being infected. HA protein has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding of these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane. Recombinant Influenza A virus (A/Anhui/1-BALF_RG45/2013 (H7N9) ) HA1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.