Recombinant human Noggin protein
NOG, also known as noggin, is a secreted protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP) -signaling pathway. It binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. This protein is an inhibitor of several bone morphogenetic proteins and cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions. It also plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors. Recombinant human Noggin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Product Name Alternative
SYM1, SYNS1, SYNS1A, NOG, symphalangism 1, synostoses syndrome 1
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
Bioactivity
Molecular Weight
23.8kDa (211aa)
Additionnal Information
References & Citations
Zimmerman LB., et al, (1996) Cell. 86:599-606. ; ; Groppe J., et al, (2002) Nature. 420:636-642.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Neuroscience
NCBI Accession Number
NP_005441.1
Uniprot Accession Number
Q13253
Species
Human
N Terminal Sequence
Gln
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