Recombinant human Betacellulin/BTC Protein

BTC, also known as Betacellulin, is a member of epidermal growth factor receptor family and functions as a ligand for the epidermal growth factor receptor (EGFR) . As the role a EGFR, betacellulin is manifested by different form of muscles and tissues, it also has a great effect of nitrogen that is used for retinal pigment epithelial cells and vascular smooth muscle cells. While many studies attest a role for betacellulin in the differentiation of pancreatic β-cells, the last decade witnessed the association of betacellulin with many additional biological processes, ranging from reproduction to the control of neural stem cells. As a typical EGFR ligand, betacellulin is expressed by a variety of cell types and tissues, and the soluble growth factor is proteolytically cleaved from a larger membrane-anchored precursor. It stimulates the proliferation of retinal pigment epithelial and vascular smooth muscle cells but did not stimulate the growth of several other cell types, such as endothelial cells and fetal lung fibroblasts. Recombinant human Betacellulin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.