Recombinant human LYVE-1 protein
LYVE-1 is also known as XLKD1 and may function in lympathic hyaluronan transport and have a role in tumor metastasis. This Protein is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. It is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels but is also observed in normal liver blood sinusoids, and embryonic blood vessels. It is selective marker of the lymphatic endothelium, is a surface endocytic receptor for hyaluronan (HA), which is an extracellular glycosaminoglycan involved in cell adhesion and migration. Recombinant human LYVE-1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
23.9kDa (220aa)
Additionnal Information
References & Citations
Chen L. et al. (2005) Invest. Ophthalmol Vis. Sci. 46:4536-4540.; ; Banerji S. et al. (1999) J. Cell Biol. 144:789-801.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_006682.2
Uniprot Accession Number
Q9Y5Y7
Species
Human
N Terminal Sequence
Ala
AA Sequence
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